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KMID : 1188320130070040458
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Gut and Liver
2013 Volume.7 No. 4 p.458 ~ p.461
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Durability of Sustained Virologic Response in Chronic Hepatitis C
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Ahmet Uyanikoglu
Sabahattin Kaymakoglu
Ahmet Danalioglu
Filiz Akyuz
Fatih Ermis
Binnur Pinarbasi
Kadir Demir
Fatih Besisik
Yilmaz Cakaloglu
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Abstract
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Background/Aims:The aim of this study is to investigate the rate of sustained virologic response (SVR) in chronic hepatitis C patients receiving antiviral treatment.
Methods:The files of patients with chronic hepatitis C treated with interferon±ribavirin between 1995 and 2009 were reviewed retrospectively. Six months after the end of treatment, patients with negative hepatitis C virus (HCV)-RNA (<50 IU/mL, as determined by the polymerase chain reaction method) were enrolled in the study.
Results:The mean age of 196 patients (89 males) was 46.13±11.10 years (range, 17 to 73 years). In biopsies, the mean stage was 1.50±0.94; histological activity index was 7.18±2.43. In total, 139 patients received pegylated interferon (IFN)+ribavirin, 21 patients received classical IFN+ribavirin, and 36 patients received IFN alone. The HCV genotypes of 138 patients were checked: 77.5% were genotype 1b, and 22.5% were other genotypes. After achievement of SVR, the median follow-up period was 33.5 months (range, 6 to 112 months), and in this period relapse was only detected in two patients (1.02%) at 18 and 48 months after treatment.
Conclusions:In total, 98.9% of patients with SVR in chronic hepatitis C demonstrated truly durable responses over the long-term follow-up period of 3 years; relapsed patients had intermittent or low-grade viremia.
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KEYWORD
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Chronic hepatitis C, Interferons
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